2024

Structure of the human K2P13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

Roy-Chowdhury S, Jang S, Abderemane-Ali F, Naughton F, Grabe M, Minor DL Jr.

BioRxiv (pre-print). 2024. DOI: https://doi.org/10.1101/2024.06.26.600491

2023

EMC chaperone-CaV structure reveals an ion channel assembly intermediate

Chen Z, Mondal A, Abderemane-Ali F, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL Jr.

Nature. 2023. DOI: 10.1038/s41586-023-06175-5

2022

Definition of a saxitoxin (STX) binding code enables discovery and characterization of the Anuran saxiphilin family.

Chen Z*, Zakrzewska S*, Hajare HS, Alvarez-Buylla A, Abderemane-Ali F, Bogan M, Ramirez D, O’Connell LA, Du Bois J, Minor DL Jr.

Proceedings of the National Academy of Sciences of the United States of America. 2022. DOI: 10.1073/pnas.2210114119

(*equal contribution)

2021

Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation.           

MacKenzie TMG*, Abderemane-Ali F*, Garrison CE*, Minor DL Jr, Du Bois J.

Cell Chemical Biology. 2021. DOI: 10.1016/j.chembiol.2021.12.003

(*equal contribution)

Evidence that toxin resistance in poison birds and frogs is not rooted in sodium channel mutations and may rely on "toxin sponge" proteins.

Abderemane-Ali F, Rossen ND, Kobiela ME, Craig RA, Garrison CE, Chen Z, Colleran CM, O'Connell LA, Du Bois J, Dumbacher JP, Minor DL Jr.

Journal of General Physiology. 2021. DOI: 10.1085/jgp.202112872

Highlighted in: Nature, National Geographic, LiveScience, The Times UK, Eurekalert, Inverse, and UCSF press.

2020

K2P channel C-type gating involves asymmetric selectivity filter order-disorder transitions.

Lolicato M*, Natale AM*, Abderemane-Ali F, Crottès D, Capponi S, Duman R, Wagner A, Rosenberg JM, Grabe M, Minor DL Jr.

Science advances. 2020. DOI: 10.1126/sciadv.abc9174  

(*equal contribution)

Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism.

Malak AO*, Abderemane-Ali F*, Wei Y, Coyan FC, Pontus G, Shaya D, Marionneau C, Loussouarn G.

Scientific Reports. 2020. DOI: 10.1038/s41598-020-62615-6

(*equal contribution)

2019

A selectivity filter gate controls voltage-gated calcium channel calcium-dependent inactivation.

Abderemane-Ali F, Findeisen F, Rossen ND, Minor DL Jr.

Neuron. 2019. DOI: 10.1016/j.neuron.2019.01.011

2018

A calmodulin C-lobe Ca2+-dependent switch governs KV7 channel function.

Chang A*, Abderemane-Ali F*, Hura GL, Rossen ND, Gate RE, Minor DL Jr.

Neuron. 2018. DOI: 10.1016/j.neuron.2018.01.035  

(*equal contribution)

2017

Stapled voltage-gated calcium channel (CaV) α-interaction domain (AID) peptides pct as selective protein-protein interaction inhibitors of CaV Function.

Findeisen F, Campiglio M, Jo H, Abderemane-Ali F, Rumpf CH, Pope L, Rossen ND, Flucher BE, DeGrado WF, Minor DL Jr.

ACS Chemical Neuroscience. 2017. DOI: 10.1021/acschemneuro.6b00454

2014

A long QT mutation substitutes cholesterol for phosphatidylinositol-4,5-bisphosphate in KCNQ1 channel regulation.

Coyan FC, Abderemane-Ali F*, Amarouch MY*, Piron J, Mordel J, Nicolas CS, Steenman M, Mérot J, Marionneau C, Thomas A, Brasseur R, Baró I, Loussouarn G.

PLoS One. 2014. DOI: 10.1371/journal.pone.0093255

(*equal contribution)

2013

Structure of a prokaryotic sodium channel pore reveals essential gating elements and an outer ion binding site common to eukaryotic channels.

Shaya D*, Findeisen F*, Abderemane-Ali F, Arrigoni C, Wong S, Nurva SR, Loussouarn G, Minor DL Jr.

Journal of Molecular Biology. 2013. DOI: 10.1016/j.jmb.2013.10.010

(*equal contribution)

2012

Dual effect of phosphatidylinositol (4,5)-bisphosphate PIP2 on Shaker K+ channels.

Abderemane-Ali F, Es-Salah-Lamoureux Z, Delemotte L, Kasimova MA, Labro AJ, Snyders DJ, Fedida D, Tarek M, Baró I, Loussouarn G.

Journal of Biological Chemistry. 2012. DOI: 10.1074/jbc.M112.382085

Opposite effects of the S4-S5 linker and PIP2 on voltage-gated channel function: KCNQ1/KCNE1 and other channels.

Choveau FS, Abderemane-Ali F, Coyan FC, Es-Salah-Lamoureux Z, Baró I, Loussouarn G.

Frontiers in Pharmacology. 2012. DOI: 10.3389/fphar.2012.00125

2011

KCNQ1 channels voltage dependence through a voltage-dependent binding of the S4-S5 linker to the pore domain.

Choveau FS, Rodriguez N, Abderemane-Ali F, Labro AJ, Rose T, Dahimène S, Boudin H, Le Hénaff C, Escande D, Snyders DJ, Charpentier F, Mérot J, Baró I, Loussouarn G.

Journal of Biological Chemistry. 2011. DOI: 10.1074/jbc.M110.146324